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KMID : 0370020010150000023
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Chung-Ang Journal of Pharmacal Sciences
2001 Volume.15 No. 0 p.23 ~ p.30
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Cardiovascular response in cerebral ischemic rats
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Lee, Nam In/이남인
Kim, Jeong Soo/Park, Sun Young/Sung, Ji Hyun/Lee, Doo Won/Bae, Ki Lyong/Sohn, Uy Dong/김정수/박선영/성지현/이두원/배기룡/손의동
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Abstract
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We investigated the cardiovascular response in ischemic rats. Ischemia was induced by both carotid arteries occlusion for 24h following reperfusion. The Blood Pressure (BP) in ischemic rats after 24h of common carotid artery occlusion was decreased
When compared to normal value, whereas the Heart Rate(HR) was not different between two groups. Aminoguanidine or MK801 had no effect on BP or HR, but nimodipine reduced BP. There was no difference The effect of aminoguanidire, nimodipine, or MK-801, on BP and HR between normal rats and ischemic rats.
In summary, the basal BP was decreased in ischemic rats but HR was not different from normal control, suggesting that increased NOx in brain of ischemic rat may result in the hypotension.
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KEYWORD
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